Combining scientific exposition with science fiction narrative, First Men to the Moon opens with an extended question-and-answer introduction in which Wernher von Braun addresses readers' questions about rocket propulsion, space navigation, weightlessness biology, cosmic radiation, and the philosophical stakes of space exploration. The story itself, divided into three chapters, follows John Mason and Larry, two American pilots undertaking the first crewed journey to the Moon, from launch at a Pacific atoll to lunar surface exploration and a hypersonic return to Earth. Each fictional episode is paired with precise technical diagrams, giving the book a documentary value that transcends its narrative framework.